IDENTIFIKASI SILDENAFIL SITRAT DALAM KOPI BUBUK DAN PRODUK OLAHANNYA YANG BEREDAR DI KOTA PALU MENGGUNAKAN METODE SOLID PHASE EXTRACTION (SPE) KROMATOGRAFI LAPIS TIPIS (KLT) DAN SPEKTROFOTODENSITOMETRI

Identification Of Sildenafil Citrate in Coffee Powder And Its Processed Products Circulating In Palu City Using Solid Phase Extraction (SPE) Method Thin Layer Chromatography (TLC) And Spectrophotodensitometry

Authors

  • Erfan Mbealo Universitas Terbuka
  • Qabul Dinanta Utama Universitas Mataram

DOI:

https://doi.org/10.29303/profood.v8i2.274

Keywords:

coffee, sildenafil, Silica gel 60 F254, spectrophotodensitometry, TLC

Abstract

Coffee is a kind of beverage made from roasted and ground coffee beans. In the Regulation of the Head of  POM No. 21 of 2016 concerning food categories, and Regulation of the Minister of Industry of the Republic of Indonesia number 03/M-IND/PER/1/2016, instant coffee (pure without being mixing with other ingredients) including decaffeinated instant coffee either in retail packaging or in bulk form is required to meet the Standard National Indonesia (SNI) 2983 : 2014. As one of the food products, coffee must safe from any chemical substances that can be harmful to human health. One of the chemical substances that commonly add to instant coffee was sildenafil. This research is non-experimental descriptive of 20 samples of coffee circulating in the city of Palu which was carried out using thin layer chromatography (TLC)-solid phase extraction (SPE) and spectrophotodensitometry methods. The analysis of the results carried out is a qualitative analysis of the chemical content of the sildenafil type of drug contained in coffee products circulating in the city of Palu. Of the 20 samples tested, 3 test samples were declared positive where the retention factor (Rf) value of the test solution spot was the same as the Rf value of the standard solution spot. and spiked sample solution. Testing with Spectrophotodensitometry provides a spectrum profile and maximum absorption wavelength of the test solution spots are the same as the standard solution spots and spiked sample solutions

References

Badan Pengawas Obat dan Makanan (2011). Metode analisis nomor 66/PA/11 : Identifikasi sildenafil sitrat, Tadalafil sitrat dan vardenafil klorida dalam kopi bubuk dan produk olahannya secara Thin layer Cromatography(TLC) dan Liquid Chromatography Mass Spectrometry (LC-MS) . Jakarta, Badan Pengawas Obat dan Makanan.

Badan Pengawas Obat dan Makanan (2013). Metode analisis nomor 29/OTPK/17 Identifikasi sildenafil sitrat, tadalafil dan vardenafil hidroklorida dalam obat tradisional dan suplemen kesehatan sediaan cair secara kromatografi lapis tipis, spektrofotodensitometri dan kromatografi cair kinerja tinggi detektor photo diode array(PDA). Jakarta, Badan Pengawas Obat dan Makanan

Badan Pengawas Obat dan Makanan (2013). Metode analisis nomor 45/OT/13 : Identifikasi Dan Penetapan Kadar Norasetildenafil,Vardenafil Hidroklorida,Sildenafil Sitrat, Thiosildenafil, Thiodimetil Sildenafil, dan tadalafil dalam obat tradisional sediaan padat melalui pemisahan dengan SPE secara LC-MS/MS. Jakarta, Badan Pengawas Obat dan Makanan.

Badan Pengawas Obat dan Makanan (2016). Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia nomor 21 Tahun 2016 Tentang Kategori Pangan. Jakarta, Badan Pengawas Obat dan Makanan

Badan Pengawas Obat dan Makanan (2017). Metode analisis nomor 31/OTPK/17: Identifikasi Sildenafil Sitrat, Tadalafil, Vardenafil, Hidroklorida, Thiosildenafil, Aminotadalafil,Norasetildenafil,Thiodimetilsildenafil,Hidroksihomosildeafil, Hidroksithiohomosildenafil, Propoksifenil Hidroksihomosildenafil, Metil Testoteron, Dan Yohimbin Hidroklorida Dalam Obat Tradisional Dan Suplemen Kesehatan Sediaan Padat Dan Cair Secara Kromatografi Lapis Tipis Dan Spektrofotodensitometri. Jakarta, Badan Pengawas Obat dan Makanan

Corporation, Restek (2022). The Fundamentals of Solid Phase Extraction (SPE) Restek Corporation

Dachriyanus, Meri Susanti.(2019) Kromatografi cair kerja Tinggi. Lembaga Pengembangan Teknologi Informasi dan Komunikasi Universitas Andalas

Husna,F. Ranawulan. Mita,S. (2020). Identifikasi Bahan Kimia Obat Dalam Obat Tradisional Stamina Pria Dengan Metode Kromatografi Lapis Tipis. Farmaka (18) 2

Jamilatur Rohmah & Chylen Setiyo Rini (2020) Buku ajar kimia analisis. Universitas muhammadiyah sidoarjo

K,Simpson, M Wells, Martha J. Nigel J. K. (2000). Introduction to Solid-Phase Extraction The Sample Preparation Problem Solid-Phase Extraction. Taylor & Francis Group LLC

Kementerian Perindustrian Republik Indonesia (2016) Pemberlakuan Standar Nasional Indonesia (SNI) Kopi Instan Secara Wajib. Jakarta Menteri Perindustrian Republik Indonesia

Kulsum, I. Suryana, S. Soni, D. (2022) Review: Moleculary Imprinted Polymer Solid Phase Extraction (MIP-SPE) untuk Pengujian Glibenklamid dalam Cairan Biologis. Jurnal Sains dan Kesehatan 4(2) 205-2013

Kurnia S, Henry, Marcella K, Neysa S, Emil (2018).Validasi Metode Identifikasi Sildenafil Sitrat, Tadalafil dan Fenilbutazon dalam Jamu Obat Kuat Secara Kromatografi Lapis Tipis-Densitometri. journal of pharmacy science and practice , 7(1) 1 - 7

Nugroho, Agung (2017). Buku Ajar Teknologi Bahan Alam. Lambung Mangkurat University Press

Nur Patria Tjahjani, (2021) Analisis Perbedaan Kadar Kafein Pada Kopi Bubuk Hitam dan Kopi Bubuk Putih Instan Secara Spektrofotometri UV-Vis. Cendikia jurnal Pharmacy 5(1), 52-62

Rahmatia, T. (2016)Metode SPE (Solid Phase Extraction) Sebagai Alternatif Terbaru Dalam Analisis Dan Pemurnian Senyawa Obat. Farmaka Suplemen,14(2),151-171.

Reni Septiani, (2021)Validasi Metode Identifikasi Kafein, Parasetamol, Sildenafil Sitrat, Tadalafil dan Vardenafil HCl Secara Simultan Dalam Obat Tradisional Stamina Pria dengan Kromatografi Lapis Tipis-Densitometri. 1(1), 1-7.

Savitri, Asri. Megantara, Sandra (2019). Metode KLT-Densitometri Sebagai Penetapan Kadar Bahan Aktif Sediaan Farmasi. Farmaka 17(2),1-14

Simpson, Nigel J. K. (2000).Solid-phase extraction : principles, techniques, and applications. Marcel Dekker, Inc.

Standar Nasional Indonesia (2014). SNI 2983:2014-Kopi Instan. Jakarta. Badan Standarisasi Nasional

Utama, Q. D., Zainuri, Z., Paramartha, D. N. A., Widyasari, R., & Aini, N. (2022). Dekafeinasi Kopi Robusta (Coffea Canephora) Lombok Menggunakan Sari Labu Siam (Sechium edule). Pro Food, 8(1), 77–87. https://doi.org/10.29303/profood.v8i1.253

Waris, R. Kadir, A. Akbar, C (2013). Identifikasi Dan Penetapan Kadar Sildenafil Sitrat Pada Jamu Kuat Lelaki Yang Beredar Di Kota Makassar. Jurnal As-Syifaa 05(01), 95-102

Published

2022-11-30

How to Cite

Mbealo, E., & Utama, Q. D. . (2022). IDENTIFIKASI SILDENAFIL SITRAT DALAM KOPI BUBUK DAN PRODUK OLAHANNYA YANG BEREDAR DI KOTA PALU MENGGUNAKAN METODE SOLID PHASE EXTRACTION (SPE) KROMATOGRAFI LAPIS TIPIS (KLT) DAN SPEKTROFOTODENSITOMETRI: Identification Of Sildenafil Citrate in Coffee Powder And Its Processed Products Circulating In Palu City Using Solid Phase Extraction (SPE) Method Thin Layer Chromatography (TLC) And Spectrophotodensitometry. Pro Food, 8(2), 60–72. https://doi.org/10.29303/profood.v8i2.274